ABSTRACT Precision agriculture can improve the decision-making process in agricultural production, as it gathers, processes and analyzes spatial data, allowing, for example, specific fertilizer application in each location. One of the proposals to deal with spatial heterogeneity of the soil or the distribution of chemical properties is to define application zones (homogeneous subareas). These zones allow reducing both spatial variability of the yield of the crop under study and of the environmental impacts. Considering the soil data, application zones can also represent strata or indicators to direct future soil sampling, thus seeking sample size reduction, for example. This study aimed to obtain an optimized sampling redesign using application zones generated from the assessment of five clustering methods (Fuzzy C-means, Fanny, K-means, McQuitty and Ward). Soil samples were collected in an agricultural area located in the city of Cascavel-Paraná-Brazil, and analyzed in the laboratory to determine the soil chemical properties, referring to four soybean harvest years (2013-2014, 2014-2015, 2015-2016 and 2016-2017). The application zones were obtained through a dissimilarity matrix that aggregates information about the Euclidean distance between the sample elements and the spatial dependence structure of the properties. Subsequently, an optimized sampling redesign, with reduction of the initial sample points, was obtained in these application zones. For the harvest years under study, the K-means and Ward clustering methods efficiently defined the application zones, dividing the study area into two or three application zones. Among the reduced sample configurations obtained by the optimization process, when comparing the initial sample configuration, the one optimized by 25 % (selecting 75 % of the initial configuration points, which corresponds to 76 sample points) was the most effective in terms of the accuracy indices (overall accuracy, Kappa, Tau). This fact indicates greater similarity between the thematic maps of these sample configurations. In this way, the reduced sample configurations could be used to generate the application zones and reduce the costs regarding the laboratory analyses involved in the study.

Abstract This study evaluates the economic viability of sheep finishing systems on irrigated Tamani grass pasture under continuous stocking, using castor bean cake. Four production systems were simulated: sheep supplemented with soybean meal on pasture fertilized with urea (SMUR), sheep supplemented with detoxified castor bean cake on pasture fertilized with urea (CCdUR), sheep supplemented with soybean meal on pasture fertilized with in natura castor bean cake (SMCC) and sheep supplemented with detoxified castor bean cake on pasture fertilized with in natura castor bean cake (CCdCC). A minimum unit of 3 hectares and an average slaughter weight of 28 kg were considered. A minimum selling price, at which the least profitable system would become profitable, was stablished: US$ 2.38 and US$ 4.45/kg per kilogram of body weight and carcass weight equivalent, adopting a minimum rate of return of 3.5% per year, based on the Selic rate. The costs for organic fertilization were 46.01% higher than in systems using chemical fertilization. The selling of live animals was not attractive in any of the systems evaluated, and the opposite was observed for the selling of carcasses and non-carcass components. System SMUR proved to be more profitable, with a gain of US$ 0.53 per kg carcass.

Resumo Objetivou-se avaliar a economicidade de sistemas de terminação de ovinos em pastagem irrigada de capim-tamani sob lotação contínua, utilizando torta de mamona. Foram simulados quatro sistemas de produção: ovinos suplementados com farelo de soja e o pasto adubado com ureia (FSUR), ovinos suplementados com torta de mamona destoxificada e o pasto adubado com ureia (TMdUR), ovinos suplementados com farelo de soja e o pasto adubado com torta de mamona in natura (FSTM) e ovinos suplementados com torta de mamona destoxificada e o pasto adubado com torta de mamona in natura (TMdTM). Foi considerada a unidade mínima de 3 hectares e determinado um peso médio ao abate de 28 kg de peso corporal. Estabeleceu-se um preço de venda mínimo, no qual o sistema de criação menos lucrativo se tornasse rentável de 2,38 e 4,45 dólares por quilograma de peso corporal e por equivalente de peso da carcaça, dotando uma taxa mínima de atratividade de 3,5% ao ano, com base na taxa Selic. Os custos com adubação orgânica, em média, são 46,01% superiores aos sistemas que utilizam adubação química. A venda de animais vivos não é atrativa em nenhum dos sistemas avaliados, sendo o contrário observado para a comercialização de carcaças e dos não componentes da carcaça de ovinos. O sistema de produção FSUR se mostrou mais lucrativo, com ganho de US$ 0.53 centavos por kg de carcaça.

ABSTRACT The study evaluated the resilient performance in terms of continuity of care and longitudinal care for Noncommunicable Chronic Diseases (systemic arterial hypertension and Diabetes Mellitus) by primary health care units in a vulnerable region of the city of Rio de Janeiro, during the COVID-19 pandemic. It is a cross-sectional mixed methods study, with a quantitative and qualitative approach. Despite the total or partial interruption potentially exposing users to acute and chronic complications, the study points out that the strategies developed by the first level of care of the basic health units in the municipality were effective in reducing hospitalizations for those diseases, demonstrating a resilient performance.

RESUMO O estudo avaliou o desempenho resiliente quanto à continuidade da atenção e ao cuidado longitudinal, às Doenças Crônicas Não Transmissíveis (hipertensão arterial sistêmica e Diabetes Mellitus) pelas unidades de atenção básica à saúde de uma região vulnerável do município do Rio de Janeiro, durante a pandemia da Covid-19. Trata-se de um estudo transversal, de métodos mistos, de abordagem quantitativa e qualitativa. Apesar de a interrupção total ou parcial potencialmente expor os usuários a complicações agudas e crônicas, o estudo aponta que as estratégias desenvolvidas pelo primeiro nível de atenção das unidades básicas de saúde do município foram efetivas para a redução de internações por essas enfermidades, demonstrando um desempenho resiliente.

RESUMO Contexto A constipação idiopática crônica (CIC) é uma condição que afeta amplamente a população global, representa um grande custo econômico, causa substancial utilização de recursos em saúde e impacta o bem-estar do indivíduo. Objetivo Revisar os consensos de Sociedades de especialistas e diretrizes publicados sobre o diagnóstico e tratamento da CIC em adultos, buscando auxiliar o raciocínio e a tomada de decisão para a conduta médica frente ao paciente e oferecer um material prático de referência. Métodos Uma força tarefa médica brasileira realizou uma busca na literatura científica nas bases de dados eletrônicos Medline/PubMed, SciELO, Embase e Cochrane, tendo sido utilizados os seguintes descritores: chronic constipation, diagnosis, management of chronic constipation. Adicionalmente, foi realizada uma revisão de artigos sobre o mecanismo de ação, segurança e eficácia das opções terapêuticas disponíveis no Brasil. Resultados A abordagem diagnóstica e o entendimento da fisiopatologia presente na CIC são itens fundamentais para que seja indicada a terapêutica apropriada e seja compreendido o ecossistema de necessidades do paciente. Conclusão A CIC é uma condição comum em adultos, ocorrendo com maior frequência em idosos e mulheres. O manejo correto é definido pela anamnese e exame físico detalhados, juntamente com a terapêutica apropriada, independentemente de ser farmacológica ou não, conforme o melhor momento de indicação. Desta forma, o impacto na qualidade de vida também é otimizado.

ABSTRACT Background Chronic idiopathic constipation (CIC) is a condition that widely affects the global population, represents relevant healthcare resource utilization and costs, and impacts the individual’s well-being. Objective To review the consensus of expert societies and published guidelines on the diagnosis and treatment of CIC in adults, seeking to assist reasoning and decision-making for medical management of patients with CIC and provide a practical reference material. Methods A Brazilian medical task force searched the scientific literature in the following electronic databases: MEDLINE/PubMed, SciELO, EMBASE and Cochrane, using the following descriptors: chronic constipation, diagnosis, management of chronic constipation. In addition, a review of articles on the mechanism of action, safety, and efficacy of therapeutic options available in Brazil was carried out. Results The diagnostic approach and the understanding of the pathophysiology present in CIC are essential items to indicate the appropriate therapy and to understand the ecosystem of the patient’s needs. Conclusion CIC is a common condition in adults, occurring more frequently in the elderly and in women. Proper management is defined by detailed medical history and physical examination, together with appropriate therapeutics, regardless pharmacological or not, and depending on the best moment of indication. This way, the impact on quality of life is also optimized.

ABSTRACT The study evaluated the resilient performance in terms of continuity of care and longitudinal care for Noncommunicable Chronic Diseases (systemic arterial hypertension and Diabetes Mellitus) by primary health care units in a vulnerable region of the city of Rio de Janeiro, during the COVID-19 pandemic. It is a cross-sectional mixed methods study, with a quantitative and qualitative approach. Despite the total or partial interruption potentially exposing users to acute and chronic complications, the study points out that the strategies developed by the first level of care of the basic health units in the municipality were effective in reducing hospitalizations for those diseases, demonstrating a resilient performance.

RESUMO O estudo avaliou o desempenho resiliente quanto à continuidade da atenção e ao cuidado longitudinal, às Doenças Crônicas Não Transmissíveis (hipertensão arterial sistêmica e Diabetes Mellitus) pelas unidades de atenção básica à saúde de uma região vulnerável do município do Rio de Janeiro, durante a pandemia da Covid-19. Trata-se de um estudo transversal, de métodos mistos, de abordagem quantitativa e qualitativa. Apesar de a interrupção total ou parcial potencialmente expor os usuários a complicações agudas e crônicas, o estudo aponta que as estratégias desenvolvidas pelo primeiro nível de atenção das unidades básicas de saúde do município foram efetivas para a redução de internações por essas enfermidades, demonstrando um desempenho resiliente.

RESUMO CONTEXTO: Lubiprostona é um ativador de canal de cloreto tipo 2 que tem se demonstrado eficaz e seguro no tratamento da constipação crônica. OBJETIVO: Revisar sistematicamente ensaios clínicos randomizados (ECRs) avaliando a eficácia da lubiprostona para pacientes com constipação idiopática crônica (CIC), síndrome do intestino irritável com constipação predominante (IBS-C) e constipação induzida por opioide (OIC). MÉTODOS: Buscas foram conduzidas no PubMed, LILACS, Cochrane Collaboration Database e Centre for Reviews and Dissemination. ECRs de lubiprostona relatando desfechos de movimentos intestinais espontâneos (SBM) e dor ou desconforto abdominal foram considerados elegíveis. Metanálise foi realizada calculando razão de riscos e intervalos de confiança de 95%, utilizando o método de Mantel-Haenszel e modelo de efeitos aleatórios. RESULTADOS: As buscas identificaram 109 registros representando 93 publicações não-duplicadas e 11 ECRs (978 pacientes de CIC, 1366 de IBS-C e 1300 OIC, total = 3644) preencheram os critérios de inclusão. Síntese qualitativa mostrou que, para pacientes com CIC, a lubiprostona foi superior ao placebo em termos de desfechos SBM. Metanálise para CIC foi possível para os desfechos de responder completo e taxa de SBM em 24 horas, indicando superioridade da lubiprostona sobre o placebo. Para IBS-C, lubiprostona foi significativamente superior para todos os desfechos de SBM em tempos de seguimento variando de 1 semana a 3 meses. Em termos de dor abdominal, lubiprostona proporciono alívio dos sintomas significativamente melhor, particularmente após 1 mês de tratamento. Para OIC, lubiprostona foi mais efetiva do que placebo tanto para medidas de SBM quando de desconforto abdominal. CONCLUSÃO: Nossos achados demonstraram que lubiprostona é superior ao placebo em termos de frequência de SBM para CIC, IBS-C e OIC. Em termos de sintomas abdominais, o efeito mais pronunciado foi visto para dor abdominal em pacientes com IBS-C.

ABSTRACT BACKGROUND: Lubiprostone is a type 2 chloride channel activator that has been shown to be efficacious and safe in the treatment for chronic constipation. OBJECTIVE: To systematically review randomized clinical trials (RCTs) assessing efficacy of lubiprostone for patients with chronic idiopathic constipation (CIC), irritable bowel syndrome with predominant constipation (IBS-C) and opioid-induced constipation (OIC). METHODS: Searches were conducted in PubMed, LILACS, Cochrane Collaboration Database, and Centre for Reviews and Dissemination. Lubiprostone RCTs reporting outcomes of spontaneous bowel movements (SBM) and abdominal pain or discomfort were deemed eligible. Meta-analysis was performed calculating risk ratios and 95% confidence intervals, using the Mantel-Haenszel method and random effects model. RESULTS: Searches yielded 109 records representing 93 non-duplicate publications, and 11 RCTs (978 CIC, 1,366 IBS-C, 1,300 OIC, total = 3,644) met inclusion criteria. Qualitative synthesis showed that for CIC patients, lubiprostone is superior to placebo in terms of SBM outcomes. Meta-analysis for CIC was feasible for full responder and SBM within 24h rates, indicating superiority of lubiprostone over placebo. For IBS-C, lubiprostone was significantly superior for all SBM outcomes in follow-ups ranging from 1 week-3 months. In terms of abdominal pain, lubiprostone provided significantly better symptoms relief, particularly after 1 month of treatment. For OIC, lubiprostone was more effective than placebo for both SBM and discomfort measures. CONCLUSION: Our findings demonstrated that lubiprostone is superior to placebo in terms of SBM frequency for CIC, IBS-C and OIC. In terms of abdominal symptoms, the most pronounced effect was seen for abdominal pain in IBS-C patients.

Imiquimod (IMQ), an immune response modifier, is used for topical treatment of basal cell carcinoma and actinic keratosis. The very poor aqueous solubility of imiquimod gives rise to difficulties in designing aqueous formulations with this drug. One approach that is widely used to enhance drug solubility is complexation with cyclodextrins. The formation of the inclusion complex between IMQ and β-cyclodextrin was investigated in solution and in solid state. IMQ aqueous solubility was improved in the presence of citric acid. The experimental results and molecular modeling indicated the formation of the inclusion complex in aqueous solution of citric acid pH 3.0; however, the low apparent stability constant suggested weak interaction between β-cyclodextrin and IMQ which hampered the use of this approach to improve imiquimod aqueous solubility and the development of an aqueous formulation containing IMQ in the same concentration as in the commercial product.

RESUMO CONTEXTO: A adequada ingestão de fibras está diretamente associada à saúde digestiva e é reconhecida como essencial à saúde humana (World Health Organization, 2003). A Organização Mundial da Saúde (OMS) recomenda consumo diário de fibras de ≥25 g, mas estudos prévios observaram uma ingesta de fibras no Brasil abaixo do recomendado. OBJETIVO: Descrever a ingestão, o conhecimento e as percepções sobre o consumo de fibras entre adultos brasileiros. MÉTODOS: Inquérito nacional online com indivíduos brasileiros na comunidade. O inquérito foi conduzido em setembro de 2018, usando uma plataforma online com questões fechadas. Uma amostra representativa dos usuários de internet no Brasil estratificada por sexo, idade, status socioeconômico e região geográfica foi utilizada. O tamanho da amostra foi calculado usando uma margem de erro de 2,0% em um intervalo de confiança de 95% (n=2.000). Os dados foram analisados descritivamente usando medidas de frequência, tendência central e dispersão. RESULTADOS: A amostra incluiu 2.000 indivíduos equilibrados em termos de sexo (51,2% mulheres), com idade média de 35,9 anos (faixa etária mais representada foi 35-54 anos, 39,6%) e de todas as regiões geográficas do país (49,4% do Sudeste). Dos respondentes, 69,7% consideram sua dieta usual como saudável e 78,4% relataram consumir fibras regularmente. Fibras de fontes naturais são consumidas pelo menos uma vez ao dia por 69,5% da amostra, enquanto que suplementos de fibras, por 29,9%. O não consumo regular de fibras foi relatado por 21,7% dos respondentes e a causa mais comum para tal foi “falta de conhecimento sobre fontes de fibras” (39,3%). Quando informados sobre fontes de fibra de cada tipo (solúvel e insolúvel) e interrogados sobre a ingestão regular, apenas 2,5% responderam não consumir nenhuma delas regularmente (por oposição a 21,7% antes de receberem informação sobre fontes específicas de fibras). CONCLUSÃO: Nossos achados indicam que a ingestão de fibras no Brasil é provavelmente insuficiente com uma alta proporção de indivíduos relatando consumo ausente ou irregular de fontes de fibras no cotidiano. Falta de conhecimento sobre fontes e tipos de fibras parece desempenhar um papel relevante nesta ingestão inadequada, reforçando a necessidade de educação nutricional para alcançar padrões alimentares saudáveis no país.

ABSTRACT BACKGROUND: Adequate fiber intake is associated with digestive health and reduced risk of several noncommunicable diseases and is recognized as essential for human health (World Health Organization, 2003). The World Health Organization (WHO) recommends a daily fiber consumption of ≥25 g, but previous studies observed a fiber intake in Brazil lower than recommended. OBJECTIVE: We aimed to describe fiber intake among adults in Brazil and also respondents’ knowledge and perceptions about their fiber intake. METHODS: National online survey with community-dwelling Brazilian individuals. The survey was conducted during September 2018, using an online platform with closed-ended questions. A representative sample of Brazilian internet users stratified by sex, age, socioeconomic status and geographic region was adopted. Sample size was calculated using a 2% error margin and 95% confidence interval (n=2,000). Data was descriptively analyzed using measures of frequency, central tendency and dispersion. RESULTS: Sample included 2,000 individuals who were well-balanced in terms of sex (51.2% female), with mean age of 35.9 years (most represented age group was 35-54 years, 39.6%) and from all country geographic regions (49.4% from Southeast). A total of 69.7% of them consider their usual diet as healthy and 78.4% reported consuming fibers regularly. Fibers from natural sources are consumed at least once a day by 69.5% of the sample, while daily fiber supplements were reported by 29.9%. Absence of regular fiber intake was reported by 21.7% of respondents and the most common reason was “lack of knowledge about fiber sources” (39.3%). When informed about the food sources of each type of fiber (soluble and insoluble) and asked about the regular intake, only 2.5% answered that they do not consume any of them regularly (as opposed to 21.7% before receiving information about specific fiber sources). CONCLUSION: Our findings indicate that fiber intake in Brazil is probably insufficient with a high proportion of individuals reporting irregular or absent ingestion of fiber sources in their daily lives. Lack of knowledge about fiber sources and fiber types seems to play a role in this inadequate intake, highlighting the need for nutritional education to achieve healthy dietary patterns in the country.

ABSTRACT This study aimed to identify whether there is an association between types of storage and categories of commercialization and use of grains, group the types of storage with the categories of commercialization, and group static and dynamic capacities of the units in the state of Paraná, Brazil. The data were obtained from the Brazilian Registry System of Storage Units for the 2014/2015 season. The association between variables under study was carried out with the chi-square test of independence and correspondence analysis. The cluster analysis consisted of the unweighted pair group method with arithmetic mean and considered a measure of mixed dissimilarity obtained for sets composed of qualitative and quantitative variables. A significant association was observed between the type of silo battery with the grain usage characteristic and cooperatives that commercialize the grain for use in the domestic market (CICOOPT); between the bulk warehouse and cooperatives that commercialize the grain in the foreign market (CIECOOPT); and between the silo and grain sellers who commercialize the grain in the domestic market (CI). Most types of storage units were grouped in Group 1, with a predominance of the CI characteristic and small to medium size static and dynamic capacity.

Abstract Plant growth can be directly influenced by the physical, chemical, and biological characteristics of their substrates. We tested the viability of using alternative substrates derived from agroindustrial residues by evaluating their effects on tomato (Solanum lycopersicum L.) germination and growth as well as the antioxidant activities in seeds and seedlings. The extracts were classified based on their principal carbon source: cotton waste (SA); sugarcane waste (SB); napier grass (SN); tree prunings (SP); and sawdust (SS). The chemical attributes of the substrates were analyzed, the physiological characteristics of tomato seed germination were determined, and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) were measured in tomato seeds and seedlings. The extracts from tree prunings and sawdust showed the highest germination indices and root lengths, while the cotton and sugarcane waste extracts showed the lowest values for the same variables, with high pH and electric conductivity values indicating possible toxicity; increased activities of antioxidant enzymes needed to correct physiological imbalances were detected. The substrates deemed most suitable for seedling production were those derived from tree prunings and sawdust.

Resumen El crecimiento de las plantas puede estar directamente influenciado por las características físicas, químicas y biológicas de sus sustratos. Probamos la viabilidad de utilizar sustratos alternativos derivados de residuos agroindustriales mediante la evaluación de sus efectos sobre la germinación y el crecimiento del tomate (Solanum lycopersicum L.), así como sobre las actividades antioxidantes de sus semillas y plántulas. Los extractos se clasificaron en función de su principal fuente de carbono: residuos de algodón (SA); desechos de caña de azúcar (SB); napier grass (SN); podas de árboles (SP); y aserrín (SS). Se analizaron los atributos químicos de los sustratos, se determinaron las características fisiológicas de la germinación de la semilla de tomate y se midieron las actividades de las enzimas antioxidantes SOD, CAT y POD en semillas de tomate y plántulas. Los extractos de poda de árboles y aserrín mostraron los índices de germinación y longitud de raíz más altos, mientras que los extractos de algodón y residuos de caña de azúcar mostraron los valores más bajos de esas mismas variables, con altos valores de pH y conductividad eléctrica que apuntan a una posible toxicidad; se detectaron actividades incrementadas de enzimas antioxidantes para corregir los desequilibrios fisiológicos. Los sustratos considerados más adecuados para la producción de plántulas fueron los basados en poda de árboles y aserrín.

ABSTRACT Spatial variability description of soil chemical properties by thematic maps depends substantially on suitable geostatistical models. One of the parameters composing a geostatistical model is nugget effect. This study aimed to evaluate the simultaneous influence of nugget effect and sampling design on geostatistical model estimation and estimation of soil chemical properties at unsampled sites, considering simulated data. Our results will be used as scientific basis for spatial variability analyses of soil chemical properties in agricultural areas. Given the simulation results and agricultural data, we concluded that the high nugget effect values obtained here reduced spatial estimation efficiency. Moreover, a systematic sampling design promoted the least accurate estimates of geostatistical model and at non-sampled sites. Despite that, these nugget effect estimates should be kept in the analysis. However, further studies will be needed to investigate which factors are responsible for such high nugget effect values.

RESUMO Objetivou-se avaliar a inclusão de soro de queijo bovino (SQB) na dieta para ovinos sobre o comportamento ingestivo, os parâmetros ruminais e sanguíneos. Vinte ovinos mestiços, machos, não castrados, com 25 kg de peso corporal foram distribuídos em quatro dietas: dieta controle (composta por milho, farelo de soja e silagem de pasto nativo) e as dietas teste (dieta controle + inclusão de SQB em níveis crescentes 1,6; 2,7 e 4,0% na MS), em um delineamento inteiramente ao acaso com quatro tratamentos e cinco repetições. A comparação de médias foi realizada pelo teste Tukey e foram testadas as correlações de Pearson entre as variáveis. Também foi feita a análise de regressão para os dados provenientes da coleta de líquido ruminal e de sangue. As avaliações de comportamento foram feitas em um intervalo de 24 horas em medições realizadas a cada cinco minutos. A inclusão de SQB na dieta não comprometeu o pH ruminal, mas promoveu a queda nos tempos de ruminação e de alimentação, ocasionando também menor número de bolos ruminais e menor número de mastigações merícicas. A menor concentração de nitrogênio amoniacal e proteínas totais foram encontradas nos ovinos que receberam a dieta com 4% de inclusão de SQB. Entretanto, esses valores ficaram dentro do padrão estabelecido para crescimento microbiano. O SQB é uma potencial alternativa proteica na alimentação de ovinos por não interferir no consumo de nutrientes, nos parâmetros ruminais e sanguíneos, e favorecer o balanço positivo de nitrogênio.

ABSTRACT The objective of this study was to evaluate the inclusion of cow cheese whey (CCW) in the diet for lambs on the ingestive behavior, ruminal and blood parameters. Twenty crossbred, male, non-castrated lambs with 25 kg body weight were assigned to four treatments: control diet (composed of corn, soybean meal and native pasture silage) and test diets (control diet + inclusion of CCW in increasing levels of 1.6, 2.7 and 4.0% in DM), in a completely randomized design with four treatments and five replications. Means were compared by Tukey’s test, and the strength of association between variables was tested by Pearson’s correlation. Regression analysis was also performed for data from the collection of ruminal fluid and blood. Behavioral assessments were made at a 24-hour interval in measurements taken every five minutes. The inclusion of CCW in the diet did not impair ruminal pH, but promoted a decrease in rumination and feeding times, also causing a lower number of cuds and a lower number of cud chews. The lowest concentration of ammonia nitrogen and total protein were found in lambs receiving the diet with 4% CCW. However, these values were within the range recommended for microbial growth. CCW is a potential protein alternative in lambs feed as it does not interfere with nutrient intake, ruminal and blood parameters, and favors a positive nitrogen balance.

Resumo O presente artigo apresenta um estudo da prestação de serviços sociais básicos do Poder Público pelo setor sem fins lucrativos como política neoliberal que impede o desenvolvimento nacional. De início, aborda a Constituição Econômica e o Estado Social e em seguida mostra o crescimento vertiginoso do setor sem fins lucrativos e das parcerias - voltadas à prestação de serviços públicos essenciais - firmadas entre o setor sem fins lucrativos e o Poder Público no Brasil nos últimos anos. Identifica o caminho da política pública brasileira para uma direção contrária ao desenvolvimento e expõe essa interligação e involução, além de abordar a administração burocrática, sua eficiência e a implementação desse modelo no Brasil. Ao final, defende o fortalecimento do Estado Social, por meio da prestação de serviços públicos sociais básicos diretamente pelo Poder Público como medida necessária a se alcançar o desenvolvimento. O estudo utiliza o método dedutivo com base em pesquisa bibliográfica e documental, tendo como referencial teórico a teoria da burocratização de Max Weber, o conceito de desenvolvimento como liberdade de Amartya Sen e a obra do filósofo André Barata, responsável pela introdução do Estado Social como instrumento frente à austeridade e garantia para sair da crise.

Abstract The paper presents a study on the realization of basic social services of the public power by the non-profit sector as a neoliberal policy that impede the national development. It begins by addressing the Economic Constitution and the Welfare State, and continues to show the rapid growth of the non-profit sector and the partnerships - focused on providing essential public services - established between the non-profit sector and the Public Power in Brazil in recent years. It identifies the path of Brazilian public policy towards a direction contrary to development and exposes this interconnection and involution, besides addressing bureaucratic administration, its efficiency and the implementation of this model in Brazil. In the end, it is advocated the realization of basic social public services directly by the Government as a necessary measure to achieve development. The study was done using the deductive method from bibliographical and documentary research, having as theoretical reference the theory of bureaucratization of Max Weber and the work of the philosopher André Barata, responsible for introducing the Welfare State as an instrument against austerity and guarantee to get out of the crisis.

ABSTRACT In the study of spatial variability of soil attributes, it is essential to define a sampling plan with adequate sample size. This study aimed to evaluate, through simulated data, the influence of parameters of the geostatistical model and sampling configuration on the optimization process, and resize and reduce the sample size of a sampling configuration of a commercial area composed of 102 points. For this, an optimization process called genetic algorithm (GA) was used to optimize the efficiency of the geostatistical model estimation based on the Fisher information matrix. The simulated data evidenced that the variation of the nugget effect or practical range did not significantly alter the sample size. GA was efficient in reducing the sample size, determining for soil chemical attributes a sample size between 30 and 40 points (29.41 to 39.22% of the initial sampling grid). The presence of spatial dependence was observed for all soil chemical attributes in the two sampling configurations (initial and optimized). The optimized sampling configuration evidenced an increase in trend intensity in the north direction and a more efficient estimation of parameters of the linear spatial regression model.

ABSTRACT Spatial variability depends on the sampling configuration and characteristics associated with the georeferenced phenomenon, such as geometric anisotropy. This study aimed to determine the influence of the sampling design on parameter estimation in an anisotropic geostatistical model and the spatial estimation of a georeferenced variable at unsampled locations. Datasets were simulated with geometric anisotropy, considering five values for the anisotropic ratio (1, 2, 3, 4, 5), and three sampling designs: lattice, random and lattice plus close pairs. The simulation results were used as a reference to select anisotropic models to describe the spatial dependence structure in chemical soil properties. For each dataset (with either simulated or chemical soil properties), the values of the georeferenced variables at unsampled locations were estimated by kriging, considering estimated isotropic and anisotropic geostatistical models. The choice of the sampling design influenced the spatial estimation of the georeferenced variable and the quality of the estimation of the geostatistical anisotropic model. The incorporation of geometric anisotropy in the spatial estimation of simulated data sets and soil chemical properties produced differences in the spatial estimation and improved the level of detail of subregions in thematic maps.